Hi, everyone. I’m delighted to announce that the Zhou Lab at Tsinghua is about to launch.
We aim to understand the principle and regulatory mechanisms of cell fate decision/transition during embryonic development and disease evolution, with new technologies of single-cell in vivo and in vitro functional identification, single-cell omics analysis and genetics strategies.
Our work mainly includes the following three directions:
- Apply and develop new single-cell multi-omics analysis to analyze the molecular expression patterns of lineage specialization during embryonic development;
- Develop in vivo and in vitro models to understand the regulatory mechanism of cell fate transition during embryonic development at the phenotypic/functional dimension;
- Explore the regulatory circuit during the embryo implantation and the evolution of reproductive tumors.
Motivated postdocs with expertise in biochemistry, molecular biology, cell biology, mouse physiology, bioinformatics or biostatistics are encouraged to apply. Please email a cover letter, your CV, and contact information for three references to zhoufanlove(AT)126.com.
The enthusiastic and down-to-earth PhD students/undergraduate interns, who are interested in joining our lab, are also welcome to contact zhoufanlove(AT)126.com directly. Please send a pdf CV.
We read every email.
Come and do some lovely research. Your place at Tsinghua yard is already reserved.
About Fan Zhou
Fan received his PhD training in hematopoietic stem cell (HSC) development at Dr. Bing Liu’s lab, Academy of Military Medical Sciences. With a developed single-cell-initiated in vivo serial transplantation system, he explored that multiple signalling pathways and transcription factor networks played critical roles during HSC emergence (Li et al., JGG, 2013, Zhou et al., Nature, 2016). Fan subsequently joined Dr. Fuchou Tang’s group at Peking University as a postdoc to study molecular regulating early human embryogenesis. Combining an in vitro simulation of implantation strategy and single-cell omics, Fan reconstituted the gene networks and DNA methylome patterns of human implantation, revealing that lineage-specific gene-expression networks in coordination with epigenetic factors (e.g. DNA methylation) might simultaneously regulate cell fate determination during implantation (Zhou et al., Nature, 2019). Fan has received a number of awards on understanding cell fate transition during embryogenesis, including the Ray Wu Prize from Ray Wu Memorial Fund (2016) and Young Elite Scientists Sponsorship Program from China Association for Science and Technology (2017). Fan will join the faculty and become a principal investigator (PI) at School of Life Sciences/Center for Life Sciences, Tsinghua University. The Zhou Lab will focus on cell fate decision during mammalian/human embryo development with single-cell in vitro/vivo functional and omics analysis.
Click here for a Google Scholar file of Fan, the official job advertisement in Chinese, Shuimu Scholar program at Tsinghua University and Postdoctoral fellowship at Tsinghua-Peking Center for Life Sciences.
Fan Zhou's Blog Site 
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